API Raw Material Esomeprazole Magnesium CAS 161973-10-0 Best Price and Fast Delivery

• CAS No.: 161973-10-0
• Formula: 2(C17h18n3o3s)2.Mg
• Environmental Protection: Yes
• Certification: ISO, SGS
• Color: White
• Classification: Supplement
• Model NO.: 161973-10-0
• Appearance: Powder
• Item: Raw Material Esomeprazole Magnesium
• Transport Package: Foil Bag/Drum/as Per Your Request
• Specification: 98%
• Trademark: IKNOW
• Origin: China
• Production Capacity: 500kg/Per Month

Product Description

API Raw Material Esomeprazole Magnesium CAS 161973-10-0 Best Price and Fast Delivery



Product Description

Esomeprazole is the latest in the class of agents called the protonpump inhibitors(PPIs). These drugs inhibit gastric hydrochloric acid secretion by binding to hydrogen- potassium adenosinetriphosphatase (H+, K+-ATPase) in gastric parietal cells. The PPIs' ability to provide rapid symptomatic control and their demonstrated efficacy in healing erosive esophagitis have led them to be viewed as agents of choice for treating patients with gastric acid-related diseases, including gastroesophageal reflux disease(GERD), gastric ulcers, and duodenal ulcers. In addition, these agents have been shown to be effective in the treatment of Zollinger-Ellison syndrome and Barrett's esophagus. Esomeprazole is the fourth PPI to be approved for use in the United States, following omeprazole; the other available PPIs are lansoprazole, pantoprazole, and rabeprazole. PPIs have similar chemical structures and a shared mechanism of action. Esomeprazole, the S-isomer of omeprazole, is the first PPI developed as a single optical isomer. Esomeprazole has an improved pharmacokinetic profile over omeprazole (a racemic mixture of Sand Roptical isomers), resulting in more potent acid suppression.

Esomeprazole, like the other PPIs, does this by accumulating in the secretory canaliculus of the parietal cell when the cell is secreting hydrochloric acid. After accumulating in this acidic environment, these agents are converted to a tetracyclic sulfenamide, which binds covalently to sulfhydryl groups of H+, K+-ATPase, rendering it inactive. The enzyme's inactivation blocks the final step of hydrochloric acid secretion into the stomach, resulting in a higher gastric pH. The covalent binding of PPIs to H+, K+-ATPase is irreversible; restoration of gastric acid production depends on the rate of de novo proton-pump regeneration, not how long plasma drug levels are maintained.

Detailed Information
 

Product Name:	Esomeprazole magnesium
Synonyms:	Esomeprazole magnesium 5-Methoxy-2-[(S)-(4-methoxy-3,5-dimethyl-2-pyridinylmethyl)sulfinyl]-1H-benzimidazole magnesium salt;Esomeprazole Magnesium(Random Configuration);Esomeprazole magnesium;Magnesium 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide;Bis(5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}benzimidazol-1-ide) magnesium;Chebi:50309;EsoMeprazole MagnesiuM(NexiuM);EsMeprazole Magne-siuM Trihydrate
CAS:	161973-10-0
MF:	2(C17H18N3O3S)2.Mg
MW:	713.12
EINECS:	627-029-7
Product Categories:	-;Esomeprazole;Inhibitors
Mol File:	161973-10-0.mol

Function

1. For gastroesophageal reflux disease (GERD).
2.Treatment of erosive reflux esophagitis in 2. cases.
3. long term maintenance of relapse in patients with esophagitis who have been cured.
4. Symptom control of gastroesophageal reflux disease (GERD) 4.
5. combined with appropriate antimicrobial therapy for the eradication of Helicobacter pylori infection related peptic ulcer healing, and to prevent recurrence.
6. the risk of gastric ulcer is reduced in patients receiving continuous NSAID treatment.
7. for the treatment of liver and stomach of the chest and diaphragm, stomach burning pain.
8. for the treatment of stomachache Tunsuan, dysphagia, hiccup.

Application

Esomeprazole magnesium (esomeprazole magnesium), also known as omeprazole, esomeprazole he left Esso chemical name, (S) - (-) -5- methoxy -2-{[(4- methyl two methoxy -3,5- -2- pyridyl) methyl] sulfinyl benzimidazole}-1H- magnesium salt, is a new type of proton pump inhibitor, can the inhibition of H+/K+-ATP activity, mainly used for the treatment of gastric acid hypersecretion induced gastric ulcer, duodenal ulcer and reflux esophagitis clinical digestive system disease.

Packing & Shipment

Quality Control of Health Sources
1) A system in accordance with GMP standard, supervision on whole production process.
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the
detailed Certificate of Analysis.
3) Procurement-Strictly on selecting raw materials.
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc
pharmaceutical and/or food standards.
5) Warehousing and storage: Clear and dry condition with suitable temperature.
6) Transportation - Audit and supervise the logistics environment to ensure storage safety.
7) Keep samples for all batches goods to be traceable in case of quality discrepance.


Certification

 

Q1:Which kind of payment terms do you accept?
For small order,you can pay by T/T or Western Union ,nomal order by T/T to our company account.

Q2:Can you give me a discount price?
Surely,It depend on your quantity.

Q3:How can I get a sample?
Free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future. 

Q4: How to confirm the Product Quality before placing orders?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests. 

Q5:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.