High-Purity Pharmaceutical Grade Citrus Extract Diosmin

• CAS No.: 520-27-4
• Formula: C28h32o15
• Environmental Protection: Yes
• Certification: ISO,SGS
• Color: Grayish Yellow or Light Yellow
• Classification: Supplement
• Function: Keeping Health and Promoting Growth
• Appearance: Powder
• Product: Powdery High Purity Extract
• Transport Package: Foil Bag/Drum/as Per Your Request
• Specification: EP8.3, Non-micronized powder
• Trademark: IKNOW
• Origin: China
• Production Capacity: 10mt/Per Month

Product Description

Description

Diosmin is a flavone, a member of the flavonoid family. Diosmin aglycone is diosmetin. It can be found in Teucrium gnaphalodes, a plant endemic to the Iberian Peninsula.

Diosmin is a semisynthetic flavonoid molecule derived from citrus d (modified hesperidin). It is an oral phlebotropic drug used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) including spider and varicose veins, leg swelling (edema), stasis dermatitis and venous ulcers. It is also used as a stand-alone or surgical adjunctive therapy in hemorrhoidal disease (HD).

Basic Information
 

Product Name	Diosmin
Source	Citrus
Specification	EP8.3,Non-micronized powder
Appearance	Hygroscopic Powder
Storage	It should be stored in a dry, clean, light-free environment
Packing	25kg
Shelf life	2 years
Applications	Capsules, tablets, granules, etc.

Product Specification
 

Product	Diosmin
Appearance	Hygroscopic Powder
Color	Grayish yellow or light yellow
Molecular Weight	608.54
CAS NO.	520-27-4
Molecular Formula	C28H32O15
Country of Origin	China
Certificate	CEP, KOSHER, ISO9001, ISO22000
Test Specifications	TS-10017-00/Ph.Eur. 8.3
Solubility	Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in ethanol (96%). It dissolves in dilute solutions of alkali hydroxides
Iodine	≤0.1%
Solution NaOH 1N	≤0.3
Density	≥0.5 g/ml
Related Substances (HPLC)	Impurity A(Acetoisovanillone)	≤0.5%
	Impurity B (Hesperidin)	≤4.0%
	Impurity C (Isorhoifolin)	≤3.0%
	Impurity D (6-iodo-diosmin)	≤0.6%
	Impurity E(Linarin)	≤3.0%
	Impurity F (Diosmetin)	≤2.0%
	Unspecified Impurities	≤0.4%
	Total impurities	≤8.5%
Heavy metalsnts	≤20ppm
Particle size	Micronized (95% < 5microns)
Water	≤6.0%
Assay on anhydrous basis	90.0%~102.0%
Packing	25kg
Production Capacity	10MT/Month

Function
 

Diosmin is a nutrient that is widely contained in citrus and that has been indicated to improve glucose metabolism in diabetic disorders. Recently, we demonstrated that diosmin induces β-endorphin to lower hyperglycemia in diabetic rats. However, the mechanisms of diosmin in opioid secretion were unclear. Therefore, we focused on the secretion of opioids from isolated adrenal glands induced by diosmin. The changes in the released β-endorphin-like immunoreactivity (BER) were determined using ELISA. Diosmin increased the BER level in a dose-dependent manner, and this effect was markedly reduced in the absence of calcium ions. Activation of the imidazoline I-2 receptor (I-2R) has been introduced to induce opioid secretion. Interestingly, we observed that diosmin activates CHO cells expressing I-R. 

Packing & Shipment

Quality Control of Health Sources
1) A system in accordance with GMP standard, supervision on whole production process.
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the
detailed Certificate of Analysis.
3) Procurement-Strictly on selecting raw materials.
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc
pharmaceutical and/or food standards.
5) Warehousing and storage: Clear and dry condition with suitable temperature.
6) Transportation - Audit and supervise the logistics environment to ensure storage safety.
7) Keep samples for all batches goods to be traceable in case of quality discrepance.


Certification

 

Q1:Which kind of payment terms do you accept?
For small order,you can pay by T/T or Western Union ,nomal order by T/T to our company account.

Q2:Can you give me a discount price?
Surely,It depend on your quantity.

Q3:How can I get a sample?
Free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future. 

Q4: How to confirm the Product Quality before placing orders?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests. 

Q5:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your los