Sales Promotion Qualified 2-Ketoglutaric Acid 328-50-7 New Batch Stock and Immediately Delivery Good Supplier

• CAS No.: 328-50-7
• Formula: C5h6o5
• EINECS: 206-330-3
• Environmental Protection: Yes
• Certification: ISO, SGS
• Color: White
• Classification: Vitamins, Amino Acids and Coenzymes
• Function: Health Supplement
• Appearance: Powder
• Grade Standard: Medicine Grade
• Product: White Crystalline Powder
• Transport Package: Foil Bag/Drum/as Per Your Request
• Specification: content≧ 98%
• Trademark: IKNOW
• Origin: China

Product Description

General Description

2-Ketoglutaric Acid also known as α-Ketoglutaric acid (AKG) is a chemical found in the body. It is a ketone derivative of the organic compound glutaric acid. It is important for the proper metabolism of all essential amino acids and the transfer of cellular energy in the citric acid or Krebs cycle. In combination with L-glutamate, AKG can reduce levels of ammonia formed in the brain, muscles, and kidneys, as well as help balance the body's nitrogen chemistry and prevent nitrogen excess in body tissues and fluids.
α-Ketoglutaric acid is used for kidney disease; intestinal and stomach disorders, including bacterial infections; liver problems; cataracts; and recurring yeast infections. It is also used for improving the way kidney patients receiving hemodialysis treatments process protein.
 

Product Name:	2-Ketoglutaric Acid
Synonyms:	ALPHA-KETOGLUTARIC ACID;GAMMA-KETOGLUTARIC ACID;FEMA 3891;KETO-GLU;PENTANEDIOIC ACID, 2-OXO-;2-Oxo-1,5-dipentanedioic acid;2-Oxo-1,5-pentanedioic acid;2-oxo-pentanedioicaci
CAS:	328-50-7
MF:	C5H6O5
MW:	146.1
EINECS:	206-330-3
Product Categories:	Pharm raw material;food additives;Pharmaceutical Intermediates;Aliphatics;Nutrition;Organic acids;Amino Acids;Food Additives

Chemical Properties

Melting point	113-115 °C
Boiling point	185.67°C (rough estimate)
Density	1.2821 (rough estimate)
Refractive index	1.3920 (estimate)
FEMA	3891 | 2-OXOPENTANEDIOIC ACID
Storage temp.	2-8°C
Solubility	H2O: soluble0.1g/mL, clear, colorless
Form	Crystalline Powder
Pka	2.47(at 25ºC)
Color	White to slightly yellow
Water Solubility	Soluble in water, methanol and dimethyl sulfoxide.

Usage

A derivative of glutaric acid.

1, Mainly as a sports nutrition beverage ingredients .
 

2,As organic intermediates, biochemical reagents, test liver function of form a complete set of reagents.
 

Benefits

1.Alanine transaminase
The alanine transaminase (ALT) enzyme converts α-Ketoglutarate and L-alanine to L-glutamate and pyruvate, respectively, as a reversible process.

2.Krebs cycle
α-Ketoglutarate is a key intermediate in the Krebs cycle, coming after isocitrate and before succinyl CoA. Anaplerotic reactions can replenish the cycle at this juncture by synthesizing α-ketoglutarate from transamination of glutamate, or through action of glutamate dehydrogenase on glutamate.

3.Formation of amino acids
Glutamine is synthesized from glutamate by glutamine synthetase, which utilizes an ATP to form glutamyl phosphate; this intermediate is attacked by ammonia as a nucleophile giving glutamine and inorganic phosphate. Proline, Arginine, and Lysine(in limited organisms) are other amino acids synthesized as well. These three amino acids derive from glutamate with the addition of further steps or with the use of enzymes to facilitate reactions.

4.Antioxidant
α-Ketoglutarate, which is known to be released by several cell types, decreased the levels of hydrogen peroxide, and the α-ketoglutarate was depleted and converted to succinate in cell culture media.

5.Longevity
A study released on May 14, 2014 links α-ketoglutarate with significantly increased lifespan in nematode worms.

Applications

1.Alpha Ketoglutaric Acid can be the great ingredient of Sports Nutritional product.
2.Alpha Ketoglutaric Acid can be the ingredients of medicine, health care products,moreover,it was a food additives.
3.Alpha Ketoglutaric Acid is a intermediate of organic synthesis.

Packing & Shipment

 

Quality Control of Health Sources

1) A system in accordance with GMP standard, supervision on whole production process.
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the
Detailed Certificate of Analysis.
3) Procurement-Strictly on selecting raw materials.
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc
Pharmaceutical and/or food standards.
5) Warehousing and storage:Clear and dry condition with suitable temperature.
6) Transportation - Audit and supervise the logistics environment to ensure storage safety.
7) Keep samples for all batches goods to be traceable in case of quality discrepance.




Certification

 

Q1:Which kind of payment terms do you accept?
For small order,you can pay by T/T or Western Union ,nomal order by T/T to our company account.

Q2:Can you give me a discount price?
Surely,It depend on your quantity.

Q3:How can I get a sample?
Free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.

Q4:How to confirm the Product Quality before placing orders?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q5:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero.If there is a real quality problem caused by us, we will send you free goods for replacement or refund yo