High Quality API 99%Min Fidaxomicin CAS 873857-62-6 Raw Material Powder

• CAS No.: 873857-62-6
• Formula: C51h72cl2o19
• Environmental Protection: Yes
• Certification: ISO, SGS
• Color: White
• Classification: Auxiliaries and Other Medicinal Chemicals
• Function: Anti-Infection
• Appearance: Powder
• Grade Standard: Medicine Grade
• Price: Competitive
• Delivery: Fast
• Storage: Cool Dried Storage
• Shelf Life: 2 Years
• Transport Package: Foil Bag/Drum/as Per Your Request
• Specification: content ≧ 99%
• Trademark: IKNOW
• Origin: China

Product Description

Introduction

Fidaxomicin (OPT-80) was approved by the U.S. FDA in May 2011 for the treatment of Clostridium difficile-associated diarrhea (CDAD), joining metronidazole and vancomycin as drugs recommended for treatment of C. difficile infections (CDI). Fidaxomicin, also known as lipiarmycin and tiacumicin, is an 18-membered macrolide natural product that was first reported in mid-1970s and is produced by fermentation. Fidaxomicin and its primary metabolite OP-1118, which results from hydrolysis of the isobutyryl ester, are narrowspectrum antibacterial agents with activity against gram-positive aerobic and anaerobic organisms, but not against gram-negative organisms. Fidaxomicin and OP-1118 exert their antibacterial activity by inhibiting bacterial RNA polymerase, thereby inhibiting bacterial protein synthesis.

API 99%Min FidaxoMicin CAS 873857-62-6

Product Name:	FidaxoMicin
Synonyms:	3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-b-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-b-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydroxy-18(S)-(1(R)-hydroxyethyl)-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaene-2-one;OPT-80;PAR-101;R-Tiacumicin B;FidaxoMicin(LipiarMycin);ClostoMicin B1, LipiarMycin A3, TiacuMicin B, OPT 80;Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-
CAS:	873857-62-6
MF:	C51H72Cl2O19
MW:	1060. 01198
Product Categories:	Inhibitors;Fidaxomicin and Impurities;
Molecular Structure:

An 18-membered macrolide that is a fermentation product obtained from the Actinomycete Dactylosporangium aurantiacum. A narrow spectrum antibiotic used for treatment of Clostridium difficile-related infections.

Chemical Properties

Density	1.33
Storage temp.	2-8°C
Form	Powder

Uses

Fidaxomicin is a recently marketed antibiotic with a confusing history dating back to its original isolation in 1975. Fidaxomicin is the major analogue of a family of macrocyclic lactones, isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic with excellent activity against Gram positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microbial flora.
 
Fidaxomycin is a natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC50s = 0.4 and 6 μM, respectively). It has potent antibacterial activity against most Gram-positive bacteria and effectively targets the Gram-positive C. difficile (MIC = 12 ng/ml). Orally administered fidaxomycin exhibits minimal systemic bioavailability resulting in maximal gastrointestinal tract distribution. Fidaxomycin is effective in clearing C. difficile infections while sparing Gram-negative bacteria in the gut.

Packing & Shipment

 

Quality Control of Health Sources

1) A system in accordance with GMP standard, supervision on whole production process.
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the
Detailed Certificate of Analysis.
3) Procurement-Strictly on selecting raw materials.
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc
Pharmaceutical and/or food standards.
5) Warehousing and storage:Clear and dry condition with suitable temperature.
6) Transportation - Audit and supervise the logistics environment to ensure storage safety.
7) Keep samples for all batches goods to be traceable in case of quality discrepance.




Certification

 

Q1:Which kind of payment terms do you accept?
For small order,you can pay by T/T or Western Union ,nomal order by T/T to our company account.

Q2:Can you give me a discount price?
Surely,It depend on your quantity.

Q3:How can I get a sample?
Free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.

Q4:How to confirm the Product Quality before placing orders?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q5:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero.If there is a real quality problem caused by us, we will send you free goods for replacement or refund you