Supply API 99%Min Everolimus CAS 159351-69-6 Raw Material Powder

• CAS No.: 159351-69-6
• Formula: C53h83no14
• EINECS: 621-003-9
• Environmental Protection: Yes
• Certification: ISO, SGS
• Color: White
• Classification: Auxiliaries and Other Medicinal Chemicals
• Function: Oncology
• Appearance: Powder
• Grade Standard: Medicine Grade, Food Grade
• Price: Competitive
• Delivery: Fast
• Storage: Cool Dried Storage
• Shelf Life: 2 Years
• Transport Package: Foil Bag/Drum/as Per Your Request
• Specification: Contains2.0%BHT, Without BHT
• Trademark: IKNOW
• Origin: China

Product Description

Introduction

Everolimus, an oral immunosuppressant for the treatment of kidney and heart transplant rejection, is the 40-O-(2-hydroxyethyl) derivative of rapamycin. It has immunosuppressive properties similar to those of rapamycin, but with improved pharmacokinetic profile. In addition, the 40-O-(2-hydroxyethyl) group alters the physico-chemical properties of the macrolide to allow galenic formulation. Everolimus is prepared in a two-step semisynthesis starting from rapamycin, by alkylation of the 40-hydroxyl group with t-butyldimethylsilyloxyethyl triflate and subsequent cleavage of the silyl protecting group. Everolimus, like rapamycin, is a proliferation signal inhibitor that exerts its immunosuppressive effect by inhibiting the activation of p70 S6 kinase, thereby blocking growth factor-driven proliferation of T cells, B cells and vascular smooth muscle cells, and arresting cell cycle at the G1 phase.

API 99%Min Everolimus CAS 159351-69-6

Product Name:	Everolimus
Synonyms:	Everolimus powder;23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv;Everolimus solution ;Everolimus, >=98%;42-O-(2-Hydroxyethyl)-rapamycin;Certica;Everolimus(mixture of isomers);Rapamycin, 42-O-(2-hydroxyethyl)-
CAS:	159351-69-6
MF:	C53H83NO14
MW:	958.232
EINECS:	621-003-9
Product Categories:	Akt;mTOR;-;All Inhibitors;Inhibitors;PI3K;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitor;Antineoplastic protein kinase inhibitors;mTOR inhibitor;Certican, Zortress, Afinitor;Anti-cancer&immunity;PI3K/Akt/mTOR;Everolimus
Mol File:	159351-69-6.mol
Molecular Structure:

A macrocyclic lactone that is rapamycin in which the hydroxy group attached to the cyclohexyl moiety has been converted to the corresponding 2-hydroxyethyl ether. It is an immunosuppressant and antineoplastic agent.

Chemical Properties

Melting point	NA
Fp	2ºC
storage temp.	−20°C
Water Solubility	Soluble in dimethysulfoxide,ethanol and chloroform. Slightly soluble in water.
Stability:	Hygroscopic

Uses

Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation

Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM

Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.

Everolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a silyl-protected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. Like all tacrolimus analogues, everolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Everolimus is extensively cited in the literature with over 2,000 citations.

Packing & Shipment

 

Quality Control of Health Sources

1) A system in accordance with GMP standard, supervision on whole production process.
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the
Detailed Certificate of Analysis.
3) Procurement-Strictly on selecting raw materials.
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc
Pharmaceutical and/or food standards.
5) Warehousing and storage:Clear and dry condition with suitable temperature.
6) Transportation - Audit and supervise the logistics environment to ensure storage safety.
7) Keep samples for all batches goods to be traceable in case of quality discrepance.




Certification

 

Q1:Which kind of payment terms do you accept?
For small order,you can pay by T/T or Western Union ,nomal order by T/T to our company account.

Q2:Can you give me a discount price?
Surely,It depend on your quantity.

Q3:How can I get a sample?
Free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.

Q4:How to confirm the Product Quality before placing orders?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q5:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero.If there is a real quality problem caused by us, we will send you free goods for replacement or refund you