Good High Purity Assay Pharmaceutical Quality Mdv3100 Enzalutamide White Powder CAS 915087-33-1

• CAS No.: 915087-33-1
• Formula: C21h16f4n4o2s
• Environmental Protection: Yes
• Certification: ISO, SGS
• Color: White
• Classification: Supplement
• Model NO.: 915087-33-1
• Appearance: Powder
• Item: Raw Material Enzalutamide
• Transport Package: Foil Bag/Drum/as Per Your Request
• Specification: 98%
• Trademark: IKNOW
• Origin: China
• Production Capacity: 500kg/Per Month

Product Description

Good High Purity Assay Pharmaceutical Quality MDV3100 Enzalutamide White Powder CAS 915087-33-1


Product Description

Enzalutamide is an androgen receptor inhibitor, the target of action is different from the approved cabbitaxel in 2010 and the approved abbitolone in 2011, and can competitively inhibit androgen and receptor binding, and can inhibition of androgen receptor nuclear transport and the interaction of the receptor and DNA. Vitro studies have shown that enzalutamide can inhibit prostate cancer cell proliferation and induce death, and enzalutamide reduces tumor volume in mouse prostate cancer xenograft model experiment. The main metabolite of enzalutamide is N-demethylol enamine, which shows similar inhibitory activity with enzalutamide in vitro. The recommended adult dose for the drug is daily 160mg, rapidly absorbed after medication, plasma concentrations to reach the highest level in 0.5~3h, the average terminal half-life is 5.8d, the main metabolic enzymes are CYP2C8 and CYP3A4. The drug should be avoided with strong CYP2C8 inhibitors (such as gemfibrozil), if it is needed for co-administration, should reduce the dose of enzalutamide to 80mg, 1 day.

Detailed Information
 

MDV-3100 Basic information

Pharmacological action Indications Clinical evaluation Side effects Biological activity In vivo studies

Product Name:	MDV-3100
Synonyms:	4-{3-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-5,5-DIMETHYL-4-OXO-2-SULFANYLIDENEIMIDAZOLIDIN-1-YL}-2-FLUO;4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N;BenzaMide,4-[3-[4-cyano-3-(trifluoroMethyl)phenyl]-5,5-diMethyl-4-oxo-2-thioxo-1-iMidazolidinyl]-2-fluoro-N-Methyl-;Enzalutamide Carboxylic acid;4-[3-(4-Ethynyl-3-trifluoromethyl-phenyl)-5,5-dimethyl-4-oxo-2-thioxo-imidazolidin-1-yl]-2-fluoro-N-methyl-benzamide;4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methylbenzamide MDV 3100;MDV3100,Menzalutamide;Xtandi (enzalutamide) (androgen receptor inhibitor)
CAS:	915087-33-1
MF:	C21H16F4N4O2S
MW:	464.4359528
EINECS:	805-022-1
Product Categories:	-;Apoptosis;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Inhibitor
Mol File:	915087-33-1.mol

Chemical and Physical Properties
Appearance	White to off-white(solid)
Quality standard	Purity 99% min

Handling and storage
Safety and Hazards	The shanghai Research Institute of Chemical industry testing center identification conclusion :1 None hazard identification, 2 The substance is not subject to IATA DGR, 3 Non packing requirements.
Handling and storage	Keep container tightly closed in a dry and well-ventilated place. Light sensitive.
Sample package	Aluminium foil bag
Commercial package	Fiber drum
UN Code	Not classfied
HS Code	29349990.90
Shipping group	Shipment at ambient temperature for no controlled and  no dangerous goods
Sales restriction	NO
Origin	China

Application
 

Application
Drug Indication	Enzalutamide is indicated for the treatment of patients with metastatic castration-resistant prostate cancer who have previously received docetaxel.
Formulations/Preparations	taken by mouth

Packing & Shipment

Quality Control of Health Sources
1) A system in accordance with GMP standard, supervision on whole production process.
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the
detailed Certificate of Analysis.
3) Procurement-Strictly on selecting raw materials.
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc
pharmaceutical and/or food standards.
5) Warehousing and storage: Clear and dry condition with suitable temperature.
6) Transportation - Audit and supervise the logistics environment to ensure storage safety.
7) Keep samples for all batches goods to be traceable in case of quality discrepance.


Certification

 

Q1:Which kind of payment terms do you accept?
For small order,you can pay by T/T or Western Union ,nomal order by T/T to our company account.

Q2:Can you give me a discount price?
Surely,It depend on your quantity.

Q3:How can I get a sample?
Free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future. 

Q4: How to confirm the Product Quality before placing orders?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests. 

Q5:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.