High Purity 99% Quality CAS 41294-56-8 Intermediates of Alfacalcidol, Vitamin D Derivative

• CAS No.: 41294-56-8
• Formula: C27h44o2
• EINECS: 255-297-1
• Environmental Protection: Yes
• Certification: ISO, SGS
• Color: White Crystal or Crystalline Powder
• Classification: Vitamin D Derivative
• Function: Osteoporosis
• Appearance: Powder
• Shelf Life: 2 Years Proper Storage
• Product: Pharmaceutical Raw Intermediates
• Transport Package: Foil Bag/Drum/as Per Your Request
• Specification: Content99%
• Trademark: IKNOW
• Origin: China

Product Description

What is Vitamin D Derivative Drugs?

Active vitamin D drugs are a general term for a series of vitamin D2/D3 derivatives, commonly referred to as "calciferol" drugs. These compounds are complex in structure and involve techniques such as photochemistry and microbial transformation. They are difficult to synthesize, sensitive to light and oxygen, and the API in the preparation is microgram-level, and the development threshold is high. Clinically used mainly for the treatment of osteoporosis, secondary hyperparathyroidism and psoriasis.

Description

Alfacalcidol is a vitamin D analog. It is important for the regulation of the bone metabolism. Alfacaldidol is a regulator of calcium and phosphorus metabolism, which helps calcium and phosphorus to be absorbed more effectively in the intestines. Thus, alfacalcidol is used to treat renal (kidney) bone diseases, rickets, osteoporosis, and patients with high or low activity of the parathyroid gland. Also, it is used to maintain normal calcium levels within the body. Alfacalcidol has significant effects on the immune system, including regulatory T cells. Alfacalcidol is furthermore used as a poultry feed additive to prevent tibial dyschondroplasia and increases phytate bioavailability.

Basic Information
 

Product Name:	Alfacalcidol
Synonyms:	5-[2E-[(3aS)-1R-[1R,5-dimethylhexyl]octahydro-7aR-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1R,3R-cyclohexanediol;Alfacalcidol/1α-Hydroxyvitamin D3;Alfacalcidol / 1α-Hydroxycholecalciferol;Vitamin D?, 1α-Hydroxy-;7,10(19)-triene-1,3-diol,(1-alpha,3-beta,5z,7e)-10-secocholesta-5;ALFACALCIDOL;ALPHACALCIDOL;1-HYDROXYCHOLECALCIFEROL
CAS:	41294-56-8
MF:	C27H44O2
MW:	400.64
EINECS:	255-297-1
Product Categories:	Inhibitors;Vitamin D3 analogs;API;Intermediates & Fine Chemicals;Pharmaceuticals;Miscellaneous Compounds
Quality Standard	EP9.0/*Y20180000715
Molecular Structure

Alfacalcidol Chemical Properties
 

Melting point	134-136°C
Storage temp.	−20°C
Solubility	Practically insoluble in water, freely soluble in ethanol (96 per cent), soluble in fatty oils.
Form	White crystalline solid
λmax	264nm(Diethyl ether)(lit.)
Merck	14,4819

Physical and Chemical Properties
White crystal or crystalline powder, insoluble in water and hexane, soluble in methanol, ethanol, chloroform, methylene chloride, acetone or ether. Perishable in case of air and light .

Uses

Synthetic analog of Calcitiol (the hormonal form of vitamin D3), which shows identical potency with respect to stimulation of intestinal calcium absorption and bone mineral mobilization.
 

Packing & Shipment

 

Quality Control of Health Sources
1) A system in accordance with GMP standard, supervision on whole production process. 
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the
Detailed Certificate of Analysis. 
3) Procurement-Strictly on selecting raw materials. 
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc
Pharmaceutical and/or food standards. 
5) Warehousing and storage: Clear and dry condition with suitable temperature. 
6) Transportation - Audit and supervise the logistics environment to ensure storage safety. 
7) Keep samples for all batches goods to be traceable in case of quality discrepance. 


Certification 

 

Q1: Which kind of payment terms do you accept? 
For small order, you can pay by T/T or Western Union, nomal order by T/T to our company account. 

Q2: Can you give me a discount price? 
Surely, It depend on your quantity. 

Q3: How can I get a sample? 
Free samples is available, but freight charges will be at your account and the charges will be return to you or deduct from your order in the future. 

Q4: How to confirm the Product Quality before placing orders? 
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests. 

Q5: How do you treat quality complaint? 
First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your

M. P.