API 99% Min Alvimopan CAS 156053-89-3 Raw Material Powder

• CAS No.: 156053-89-3
• Formula: C25h32n2o4
• EINECS: 1312995-182-4
• Environmental Protection: Yes
• Certification: ISO, SGS
• Color: White
• Classification: Auxiliaries and Other Medicinal Chemicals
• Function: Intestinal Ostruction
• Appearance: Powder
• Grade Standard: Medicine Grade, Food Grade
• Price: Competitive
• Delivery: Fast
• Storage: Cool Dried Storage
• Shelf Life: 2 Years
• Transport Package: Foil Bag/Drum/as Per Your Request
• Specification: Content≧ 99%
• Trademark: IKNOW
• Origin: China

Product Description

Introduction

Alvimopan has its chemical name being 2-[[(2S)-2-[[(3R, 4R)-4-(3-hydroxyphenyl)-3, 4-dimethyl-piperidin-1-yl] methyl]-3-phenyl-propionyl] amino] acetic acid dihydrate. It is a highly selective peripheral opioid antagonist which was jointly developed by the British company GlaxoSmithKline (GSK) and the United States Adolor company. In May 2008, it was approved by the US FDA for entering into market for applying to promote the recovering of the gastrointestinal function of patients who have been subject to colon or small intestine stage I resection anastomosis. Since the product can selectively inhibit the gastrointestinal opioid receptors without reducing the central analgesic effect of opioid agonists, therefore it does not affect the analgesic effect of systemic administration with safety and well-tolerance.

API 99%Min Alvimopan CAS 156053-89-3

Product Name:	Alvimopan
Synonyms:	((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycine;2-([(2S)-2-([(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl)-3-phenylpropanoyl]amino)acetic acid;Alvimopan;170098-38-1 (Dihydrate);Alvimopan anhydrous;Glycine, N-((2S)-2-(((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl)methyl)-1-oxo-3-phenylpropyl)-;Ly246736;trans-3,4-Dimethyl-4-(3-hydroxyphenyl) piperidine
CAS:	156053-89-3
MF:	C25H32N2O4
MW:	424.53
EINECS:	1312995-182-4
Product Categories:	Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
Molecular Structure:

Indication:  Alvimopan competitively binds to mu-opioid receptor in the gastrointestinal tract. Unlike methylnaltrexone (another peripherally acting mu-receptor antagonist) that bears a quaternary amine, alvimopan owes its selectivity for peripheral receptors to its kinetics. Alvimopan binds to peripheral mu-receptors with and dissociates slower than most other ligands.

Application

It is used to speed recovery of stomach and intestinal functions after a gastrointestinal surgery, and to prevent side effects caused by narcotic medications .

It is a gastroprokinetic, peripheral µ-opioid receptor antagonist. It reduces certain side effects of narcotic medications that are often used to prevent pain caused by surgery.

Packing & Shipment

 

Quality Control of Health Sources

1) A system in accordance with GMP standard, supervision on whole production process.
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the
Detailed Certificate of Analysis.
3) Procurement-Strictly on selecting raw materials.
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc
Pharmaceutical and/or food standards.
5) Warehousing and storage:Clear and dry condition with suitable temperature.
6) Transportation - Audit and supervise the logistics environment to ensure storage safety.
7) Keep samples for all batches goods to be traceable in case of quality discrepance.




Certification

 

Q1:Which kind of payment terms do you accept?
For small order,you can pay by T/T or Western Union ,nomal order by T/T to our company account.

Q2:Can you give me a discount price?
Surely,It depend on your quantity.

Q3:How can I get a sample?
Free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.

Q4:How to confirm the Product Quality before placing orders?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q5:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero.If there is a real quality problem caused by us, we will send you free goods for replacement or refund you