| CAS No.: | 501-30-4 |
|---|---|
| Formula: | C6h6o4 |
| Environmental Protection: | Yes |
| Color: | White |
| Function: | Keeping Health and Promoting Growth |
| Appearance: | Powder |
| Customization: |
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Product Description
Kojic acid is composed of glucose by Aspergillus Candida in 30~32 ºC under aerobic fermentation, having the antibacterial effect of organic acid, molecular structure is for substituted gamma pyrone, in naturally occurring γ-pyranone compounds, well-known compounds are only kojic acid and maltol. In 1907, Saito is by Aspergillus isolated kojic acid crystals. In 1912, it was named by Yabuta and in 1924 to determine the structure of kojic acid. In 1953, Arnstela (surface fermentation) and in1971 Kitada Makio (submerged fermentation) using isotope tracing technique converted that kojic acid is glucose without carbon frame fracture direct oxidation and dehydration to form.
Kojic acid is present in the song, it is what people eat, safe use. In recent years, application of a large number of patent documentation report kojic acid was used in cosmetics. Tyrosinase is a key enzyme in melanin formation. Kojic acid can combine with tyrosinase copper chelate and make the loss of activity, which is the whitening effect.Clinical application and experimental results show that kojic acid can generate strong inhibitory effect on human skin melanin, safe and non-toxic, will not be caused sequelae of leukoplakia. Better combination of kojic acid and other agents (such as superoxide dismutase (SOD), placenta extract, amino acids, sunscreen agents and various kinds of plant extracts, etc.). Kojic acid is mainly used for skin whitening products, anti-aging products, sunscreen products, whitening facial cleanser and cosmetics.
Kojic acid has certain antibacterial activity. Gram negative bacteria of kojic acid sodium of sensitive degree is greater than gram positive bacteria, while most other contrary in the antimicrobial substances. Inhibitory effect of kojic acid is far below other antibacterial substances and its antibacterial activity is bacteriostatic rather than sterilization. Kojic acid on yeast, virus and phage is invalid.
Detailed Information
| Product Name: | Kojic acid |
| Synonyms: | 4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-;4H-Pyran-4-one,5-hydroxy-2-(hydroxymethyl)-;5-hydroxy-2-(hydroxymethyl)-4h-pyran-4-on;kojic;Pyran-4-one, 5-hydroxy-2-(hydroxymethyl);2-HYDROXYMETHYL-5-HYDROXY-4-PYRONE;5-Hydroxy-2-(hydroxymethyl)-γ-pyrone;Kojic acid |
| CAS: | 501-30-4 |
| MF: | C6H6O4 |
| MW: | 142.11 |
| EINECS: | 207-922-4 |
| Product Categories: | Chelating Agents & Ligands;Herb extract;inhibitor;Cosmetics;Fine Chemical;Pyridines;-;FINE Chemical & INTERMEDIATES;Heterocycles;Plant Oils, Toxins, Phenolic Acids & Derivatives |
| Mol File: | 501-30-4.mol |
| Melting point | 152-155 °C(lit.) |
| Boiling point | 179.65°C (rough estimate) |
| Density | 1.1712 (rough estimate) |
| Refractive index | 1.4434 (estimate) |
| Storage temp. | Refrigerator |
| Form | Crystalline Powder |
| Pka | 7.9(at 25ºC) |
| Color | White to beige-brown |
| Water Solubility | SOLUBLE |
| λmax | 269nm(CHCl3)(lit.) |
| Merck | 14,5317 |
| BRN | 120895 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 501-30-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 5-Hydroxy-2-(hydroxymethyl)-4h-pyran-4-one(501-30-4) |
| EPA Substance Registry System | 4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)- (501-30-4) |
Function
(1) Kojic acid is a kind of specialized inhibitor for melanin. It can prevent the tyrosinase activity through synthesizing with copper ion in the cells after it enters skin cells. Kojic acid and its derivative has better inhibitory effect on tyrosinase than any other skin whitening agents. At present it is assigned into various kinds of cosmetics for curing freckles,spots on the skin of old man,pigmentation and acne.
(2) Kojic acid can also eliminate free radical, strengthen cell activity of cell and keep the food fresh.
(3) Kojic acid also has antibacterial and antifungal properties.
Application(1) Food use kojic acid may be used on cut fruits to prevent oxidative browning, in seafood to preserve pink and red colors.
(2) in cosmetics to lighten skin. As an example of the latter, it is used to treat skin diseases like melasma.
(3) Daily chemicals material Kojic acid can inhibits caseinase synthesis, then inhibits skin melanin formation, kojic acid and it's derivatives are widely used in high-quality brightening cosmetic, bath cream midtoothpaste. The products containing kojic acid can treat freckle, acne, pigmentation and macula effectively without any toxic and bad results, At present, kojic acid's use level added in cosmetic amounts to 0.2-1.0 percent.
(4) Medical use: Kojic acid also has antibacterial and antifungal properties. Kojic acid and it's derivatives are used as an important material in antibiotic - cethamycin, anodyne, and antiphlogistic production.
(5) Pesticide Biologic fertilizer with 0.51.0% Kojic acid has a clearly effect on increase production both foodstuff and greenstuff.
(6) Others Kojic acid can be film despecking agent and iron ananysis reagent.
Quality Control of Health Sources
1) A system in accordance with GMP standard, supervision on whole production process.
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the
detailed Certificate of Analysis.
3) Procurement-Strictly on selecting raw materials.
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc
pharmaceutical and/or food standards.
5) Warehousing and storage: Clear and dry condition with suitable temperature.
6) Transportation - Audit and supervise the logistics environment to ensure storage safety.
7) Keep samples for all batches goods to be traceable in case of quality discrepance.
Certification
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