High Purity 99% Vitamin D Derivative Eldecalcitol Raw Materials Powder CAS 104121-92-8

• Customization: Available
• CAS No.: 104121-92-8
• Formula: C30h50o5
• Model NO.: IK-Eldecalcitol
• Certification: ISO, SGS
• Color: White
• Classification: Antineoplastic Agents
• Function: Osteoporosis
• Appearance: Powder
• Shelf Life: 2 Years Proper Storage
• Product: Pharmaceutical Raw Intermediates
• Grade Standard: Medicine Grade, Tech Grade
• Transport Package: Foil Bag/Drum/as Per Your Request
• Specification: Content99%
• Trademark: IKNOW
• Origin: China

Product Description

What is Vitamin D Derivative Drugs?

Active vitamin D drugs are a general term for a series of vitamin D2/D3 derivatives, commonly referred to as "calciferol" drugs. These compounds are complex in structure and involve techniques such as photochemistry and microbial transformation. They are difficult to synthesize, sensitive to light and oxygen, and the API in the preparation is microgram-level, and the development threshold is high. Clinically used mainly for the treatment of osteoporosis, secondary hyperparathyroidism and psoriasis.

Description

Eldecalcitol (Edirol) was approved in January 2011 by the Japanese Ministry of Health, Labor, and Welfare for the treatment of osteoporosis. Because of vitamin D's central role in the bone health, vitamin D and analogs of vitamin D have been used to treat patients diagnosed with osteoporosis.

Synthesis
Eldecalcitol is an analog of the active form of vitamin D, calcitriol, in which the lower cyclohexane ring contains a hydroxypropyl group. The synthesis of eldecalcitol involves the assembly of two units, a fully protected (3S,4S,5R)-oct-1-en-7-yne-3,4,5-triol and a fused bicyclic system, (R)-6- ((1R,3aR,7aR,E)-4-(bromomethylene)-7a-methyloctahydro-1H-inden-1- yl)-2-methylheptan-2-ol, through a Diels-Alder reaction to give fully protected eldecalcitol. The hydroxyl groups are then deprotected to give the parent molecule. Eldecalcitol binds to the vitaminDreceptor 2.7-fold more potently than calcitriol, while only weakly inhibiting serum parathyroid hormone.

Basic information 
 

Product Name:	Eldecalcitol
CAS:	104121-92-8
MF:	C30H50O5
MW:	490.71
Quality Standard:	Internal Standard
Molecular Structure:

 
Chemical Properties
 

Melting point	126-128 ºC
Density	1.10

 

Eldecalcito Usage
 

Eldecalcitol is a new active vitamin D3 derivative for the treatment of osteoporosis.
 

Packing & Shipment

Quality Control of Health Sources
1) A system in accordance with GMP standard, supervision on whole production process. 
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the
Detailed Certificate of Analysis. 
3) Procurement-Strictly on selecting raw materials. 
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc
Pharmaceutical and/or food standards. 
5) Warehousing and storage: Clear and dry condition with suitable temperature. 
6) Transportation - Audit and supervise the logistics environment to ensure storage safety. 
7) Keep samples for all batches goods to be traceable in case of quality discrepance. 


Certification 

 

Q1: Which kind of payment terms do you accept? 
For small order, you can pay by T/T or Western Union, nomal order by T/T to our company account. 

Q2: Can you give me a discount price? 
Surely, It depend on your quantity. 

Q3: How can I get a sample? 
Free samples is available, but freight charges will be at your account and the charges will be return to you or deduct from your order in the future. 

Q4: How to confirm the Product Quality before placing orders? 
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests. 

Q5: How do you treat quality complaint? 
First of all, our quality control will reduce the quality problem to near zero.If there is a real quality problem caused by us, we will send you free goods for replacement or refund you.