| CAS No.: | 12542-36-8 |
|---|---|
| Formula: | C32h34o10 |
| Environmental Protection: | Yes |
| Certification: | ISO, SGS |
| Color: | Yellow |
| Classification: | Natural Products |
| Customization: |
|---|
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Basic Information
Gossypol is the active component extracted from cotton roots and seeds. It accounts for about 1.5% of the seeds in weight, and is mostly used as medicine in the form of Gollypol Acetate. It is a natural male contraceptive and is also used for treatment of female gynecological disorders. Clinical studies indicate that it has potent anti-tumor and anti-virus activity, and has been used for treating cancer of the adrenal cortex and cancer of the bladder.
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Product Name |
Gossypol Acetate |
CAS Number: |
12542-36-8 |
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Origin: |
Cotton Seed |
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Molecular Structure: |
|
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Molecular Formula: |
C30H30O8 .C2H4O2 |
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Molecular Weight: |
578.61 |
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Appearance: |
Yellow Powder |
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Assay by HPLC: |
98% Min |
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Solubility: |
Clear yellow solution at 25Mg/Ml in ehanol and DMF |
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Packing: |
1kg/aluminum foil package |
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Storage: |
Store in a cool and dry area, keep sealed and keep away from direct light |
About the Gossypol Acetate
1. High concentrations of gossypol, function of enzyme or protein related cell growth, cell apoptosis, but not malignant hyperplasia induced cells
2.Gossypol acetic acid can make endometrial estrogen and progesterone in the dependence of acid phosphatase (ACP), nonspecific lipase (NSE) and alkaline phosphatase (AKP) activity decline, have indirect inhibition of endometrial cells.
3, inhibition of DNA synthesis of endometrial cells
Gossypol acetic acid can inhibit endometrial cells thymine and DNA synthesis, thereby directly inhibit the growth of endometrium atrophy.
High concentrations of gaa enzyme or functional protein can be related to cell growth, cell apoptosis, but not malignant hyperplasia induced cells.
4, Gossypol acetate on the regulation of ovarian hormones has a certain role.
Is mainly for hormone receptor inhibition at early stage, patients can reduce abnormal vaginal estrogen levels, but the serum estradiol, progesterone levels before and after ovulation had no effect.After a period of treatment, the serum hormone level decreased, but the natural recovery after the drug was stopped, does not affect fertility function.
5, The original secondary dysmenorrhea treatment effect
Gossypol acetic acid can inhibit the activity of lysosomal and the synthesis of DNA, which makes arachidonic acid into prostaglandins, this step is blocked, can inhibit the synthesis of prostaglandin and thrombosis.ACTS on the endometrium, can reduce endometrium metabolites prostaglandins and thromboxane in 6 - ketone - PGF1 alpha, TXB2 a significant therapeutic effect.
Compound gossypol acetate film contains vitamin B6, the use of vitamin B6 promote magnesium ions (mg++) through the cell membrane, increase the intracytoplasmic mg++ concentration effect, so as to play to the treatment of primary dysmenorrhea.
Quality Control of Health Sources
1) A system in accordance with GMP standard, supervision on whole production process.
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the
Detailed Certificate of Analysis.
3) Procurement-Strictly on selecting raw materials.
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc
Pharmaceutical and/or food standards.
5) Warehousing and storage: Clear and dry condition with suitable temperature.
6) Transportation - Audit and supervise the logistics environment to ensure storage safety.
7) Keep samples for all batches goods to be traceable in case of quality discrepance.
Certification
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