Introduction
| Product Name: |
Pyridoxal phosphate |
| CAS: |
54-47-7 |
| MF: |
C8H10NO6P |
| MW: |
247.14 |
| EINECS: |
200-208-3 |
| Product Categories: |
Phosphorylating and Phosphitylating Agents;Vitamins and derivatives;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Molecular Structure: |
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Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions. The Enzyme commission has cataloged more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities. The versatility of PLP arises from its ability to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates.
Function
1. Clinically used to treat Parkinson's disease;
2. Promote the transaminase in transamination dopamine levels in the body;
3. Used in the treatment of acute or chronic eczema dermatitis nettle examine pustular rash itching seborrheic eczema scaly rash drug eruption deficiency oral inflammation glossitis pregnancy reaction, asthma, etc;
4. The main body of vitamin B6.
PLP acts as a coenzyme in all transamination reactions, and in certain decarboxylation, deamination, and racemization reactions of amino acids. The aldehyde group of PLP forms a Schiff-base linkage (internal aldimine) with the ε-amino group of a specific lysine group of the aminotransferase enzyme. The α-amino group of the amino acid substrate displaces the ε-amino group of the active-site lysine residue in a process known as transaldimination. The resulting external aldimine can lose a proton, carbon dioxide, or an amino acid side chain to become a quinoid intermediate, which in turn can act as a nucleophile in several reaction pathways.
In transamination, after deprotonation, the quinoid intermediate accepts a proton at a different position to become a ketimine. The resulting ketimine is hydrolyzed so that the amino group remains on the complex.
In addition, PLP is used by aminotransferases (or transaminases) that act upon unusual sugars such as perosamine and desosamine. In these reactions, the PLP reacts with glutamate, which transfers its alpha-amino group to PLP to make pyridoxamine phosphate (PMP). PMP then transfers its nitrogen to the sugar, making an amino sugar.
PLP is also involved in various beta-elimination reactions such as the reactions carried out by serine dehydratase and GDP-4-keto-6-deoxymannose-3-dehydratase (ColD).
It is also active in the condensation reaction in heme synthesis.
PLP plays a role in the conversion of levodopa into dopamine, facilitates the conversion of the excitatory neurotransmitter glutamate to the inhibitory neurotransmitter GABA, and allows SAM to be decarboxylated to form propylamine, which is a precursor to polyamines.
Quality Control of Health Sources
1) A system in accordance with GMP standard, supervision on whole production process.
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the
Detailed Certificate of Analysis.
3) Procurement-Strictly on selecting raw materials.
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc
Pharmaceutical and/or food standards.
5) Warehousing and storage:Clear and dry condition with suitable temperature.
6) Transportation - Audit and supervise the logistics environment to ensure storage safety.
7) Keep samples for all batches goods to be traceable in case of quality discrepance.
Certification
Q1:Which kind of payment terms do you accept?
For small order,you can pay by T/T or Western Union ,nomal order by T/T to our company account.
Q2:Can you give me a discount price?
Surely,It depend on your quantity.
Q3:How can I get a sample?
Free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.
Q4:How to confirm the Product Quality before placing orders?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q5:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero.If there is a real quality problem caused by us, we will send you free goods for replacement or refund you
Audited Supplier 
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