Customization: | Available |
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CAS No.: | 38821-49-7 |
Formula: | C10h16n2o5 |
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Carbidopa inhibits aromatic-L-amino-acid decarboxylase (DOPA Decarboxylase or DDC),[1] an enzyme important in the biosynthesis of L-tryptophan to serotonin and in the biosynthesis of L-DOPA to Dopamine (DA). DDC exists both outside of (body periphery) and within the confines of the blood-brain barrier.
Carbidopa is used in the treatment of, among other diseases, Parkinson's disease (PD), a condition characterized by death of dopaminergic neurons in the substantia nigra. Increased dopamine available may increase the effectiveness of the remaining neurons and alleviate symptoms for a time. The pharmacologic objective is to get an exogenous dopamine-precursor known as levodopa/L-DOPA into the dopamine-deficient brains of PD patients.
Levodopa/L-DOPA can cross the blood brain barrier, but dopamine cannot. The use of carbidopa seems counter-intuitive in Parkinson's disease (PD) in that it prevents DDC conversion of levodopa/L-DOPA to dopamine. However, exogenously provided, levadopa/L-DOPA gets metabolized peripherally to its active metabolite dopamine before reaching the blood-brain barrier.
Product InformationProduct Name | Carbidopa |
Synonyms | (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic Acid;Carbidopa SynonyMs (+)-2-(3,4-Dihydroxybenzyl)-2-hydrazinopropionic acid Monohydrate;(-)-l-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamicacidmonohydrat;(-)-l-alpha-hydrazino-3,4-dihydroxy-alpha-methyl-hydrocinnamicacimonohydr;(S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic acid monohydrate;Carbidopa for system suitability;alpha-hydrazino-3,4-dihydroxy-alpha-methyl-benzenepropanoicacimonohydra;lodosyn |
CAS No. | 38821-49-7 |
MF | C10H16N2O5 |
MW | C10H16N2O5 |
EINECS | 244.24 |
Product Categories | 642-905-9 |
Mol File | 38821-49-7.mol |
Solubility | Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of mineral acids. |
Form | Neat |
Application
Carbidopa is most commonly used as a method to inhibit the activity of dopamine decarboxylase.Carbidopa is also used in combination with 5-HTP, a naturally occurring amino acid which is a precursor to the neurotransmitter serotonin and an intermediate in tryptophan metabolism. Carbidopa prevents 5-HTP's metabolism in the liver and the resulting elevated levels of serotonin in the blood. Research shows that co-administration of 5-HTP and carbidopa greatly increases plasma 5-HTP levels. 5-HTP has no reported cases of heart valve disease associated with it as found in the peer reviewed literature;however, several cases of scleroderma-like illness have been reported in patients using carbidopa and 5-HTP.
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