Pharmaceutical Raw Material Ibrutinib CAS 936563-96-1 White Powder for Non-Small Cell Lung Cancer

• CAS No.: 936563-96-1
• Formula: C25h24n6o2
• Environmental Protection: Yes
• Color: White
• Function: Keeping Health and Promoting Growth
• Appearance: Powder
• Model NO.: 936563-96-1
• Item: Pharmaceutical Raw Material Ibrutinib
• Transport Package: Foil Bag/Drum/as Per Your Request
• Specification: 99%
• Trademark: IKNOW
• Origin: China
• Production Capacity: 500kg/Per Month

Product Description

Pharmaceutical Raw Material Ibrutinib CAS 936563-96-1 White Powder For Non-small Cell Lung Cancer


Product Description----------------------------------------------------------------------------------------------------------

Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and it presents a very promising activity in B cell malignancies. 

Ibrutinib (Imbruvica) is a small molecule drug that binds permanently to a protein, Bruton's tyrosine kinase (BTK), that is important in B cells. It is used to treat B cell cancers like mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenström's macroglobulinemia.

Detailed Information

Ibrutinib Basic Information

Bruton tyrosine kinase (BTK) inhibitor Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) Research and development process Mechanism Metabolism and Elimination Synthetic method Patents.

Product Name	Ibrutinib
Synonyms	936563-96-1;(R)-1-(3-(4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidin-1-yl)prop-2-en-1-one;1-[(3R)-3-[4-AMino-3-(4-phenoxyphenyl)pyrazolo[3, 4-d]pyriMidin-1-yl]piperidin-1-yl]prop-2-en-1-one;Ibrutinib (PCI-32765);1-{3-[4-AMino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyriMidin-1-yl]-piperidin-1-yl}-propenone;1-{3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-but-3-en-1-one;Factory supply high quality Ibrutinib Cas 936563-96-1 with best price and fast delivery;N6-(2-Carboxyethyl)
Appearance	White Crystalline Powder
CAS	936563-96-1
MF	C25H24N6O2
MW	440.5
EINECS	805-642-2
Product categories	Inhibitor;Inhibitors;-;Anticancer
Mol File	936563-96-1.mol

Ibrutinib Chemical Properties

Density	1.34
CAS DataBase Reference	936563-96-1

 

Application

Ibrutinib is a highly selective Bruton's tyrosine kinase (Btk) irreversible inhibitor.PCI-32765 (Ibrutinib) is a selective and irreversible pyrrolopyrimidine-based inhibitor of BTK with IC50 of 0.5 nM. [1] PCI-32765 binds irreversibly to Cys-481 in BTK and thus is only active with other kinases with such a modifiable cysteine residue. In DOHH2 cells, in which the BCR pathway can be activated by anti-IgG, PCI-32765 inhibits autophosphorylation of BTK (IC50, 11 nM), BTK's physiological substrate, PLCg (IC50, 29 nm), and downstream ERK (IC50, 13 nm). 

Packing & Shipment

Quality Control of Health Sources
1) A system in accordance with GMP standard, supervision on whole production process.
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the
detailed Certificate of Analysis.
3) Procurement-Strictly on selecting raw materials.
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc
pharmaceutical and/or food standards.
5) Warehousing and storage: Clear and dry condition with suitable temperature.
6) Transportation - Audit and supervise the logistics environment to ensure storage safety.
7) Keep samples for all batches goods to be traceable in case of quality discrepance.


Certification

 

Q1:Which kind of payment terms do you accept?
For small order,you can pay by T/T or Western Union ,nomal order by T/T to our company account.

Q2:Can you give me a discount price?
Surely,It depend on your quantity.

Q3:How can I get a sample?
Free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future. 

Q4: How to confirm the Product Quality before placing orders?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests. 

Q5:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.